18A
Apolipoprotein A-I mimetic peptide 18A
18 Amino Acids · MW: ~2160 Da
Amino Acids
18
Molecular Weight
~2160 Da
Half-life
Hours to <1 day in free peptide form
Research Score
4.2
Studies
55
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is 18A?
18A is a classic synthetic amphipathic helix designed to mimic apolipoprotein A-I behavior. It has been researched for improving HDL particle function and reducing cholesterol-driven vascular inflammation.
Key Benefits & Mechanisms
supports reverse cholesterol transport
improves HDL function
reduces oxidized lipid signaling
may decrease plaque progression
Research Summary
18A helped establish the apoA-I mimetic peptide field by showing that small synthetic helices can reproduce some HDL-like functions. It has been used in studies of cholesterol efflux, vascular oxidation, and plaque biology.
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