17α-Estradiol
17alpha-Estradiol
N/A Amino Acids · MW: 272.38 Da
Amino Acids
N/A
Molecular Weight
272.38 Da
Half-life
N/A (context-dependent)
Research Score
3.9
Studies
80
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is 17α-Estradiol?
17α-Estradiol is a stereoisomer of estradiol that has been studied as a sex-biased geroprotector. It is notable for lifespan effects in male mice and for modulating metabolic and inflammatory pathways linked to aging.
Key Benefits & Mechanisms
lifespan extension
metabolic modulation
inflammation reduction
sex-specific geroprotection
Research Summary
Multiple mouse studies suggest 17α-estradiol can extend lifespan and improve age-related metabolic markers, particularly in males. The compound remains a research tool rather than a general anti-aging therapy because its hormonal profile makes translation complex.
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