Thymogen vs HNP-1
Head-to-head comparison of Thymogen (L-Glutamyl-L-Tryptophan) and HNP-1 (Human Neutrophil Peptide 1 (Alpha-Defensin 1)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Thymogen | HNP-1 |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | L-Glutamyl-L-Tryptophan | Human Neutrophil Peptide 1 (Alpha-Defensin 1) |
| Molecular Weight | 345.34 Da | 3443 Da |
| Half-Life | 1-2 h | Minutes to hours; protease-sensitive |
| Amino Acids | 2 | 30 |
| Typical Dose | 100-300 mcg | Research use only; no approved human dose |
| Route | Intranasal | Topical / Research parenteral |
| Purity | ≥98% | ≥98% |
| Studies Count | 60 | 610 |
| Research Status | Clinical | Pre-clinical |
Thymogen Benefits
- ✓cellular-immune-support
- ✓t-cell-signaling
- ✓recovery-adjunct
- ✓infection-resilience
HNP-1 Benefits
- ✓neutrophil-derived antimicrobial defense
- ✓broad pathogen killing
- ✓immune cell signaling
- ✓mucosal protection
Thymogen Dosing
100-300 mcg/day|intranasal or IM|5-10 day cycles
HNP-1 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
Thymogen Side Effects
- ⚠nasal irritation
- ⚠headache
- ⚠hypersensitivity
HNP-1 Side Effects
- ⚠membrane toxicity at high concentrations
- ⚠short in vivo stability
- ⚠potential inflammation amplification
Research Overview
Thymogen
Thymogen has been studied as a short thymic peptide-like dipeptide with immunoregulatory activity. The literature focuses on lymphocyte function, cytokine modulation, and use in recurrent respiratory infections or immune suppression states.
HNP-1
HNP-1 has been studied as a key component of neutrophil-mediated host defense against bacteria, fungi, and some enveloped viruses. Literature also reports immunomodulatory effects, including impacts on chemotaxis, cytokine release, and barrier defense.
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