HNP-1 vs Indolicidin
Head-to-head comparison of HNP-1 (Human Neutrophil Peptide 1 (Alpha-Defensin 1)) and Indolicidin (Indolicidin (Bovine Neutrophil Antimicrobial Peptide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | HNP-1 | Indolicidin |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | Human Neutrophil Peptide 1 (Alpha-Defensin 1) | Indolicidin (Bovine Neutrophil Antimicrobial Peptide) |
| Molecular Weight | 3443 Da | 2111 Da |
| Half-Life | Minutes to hours; protease-sensitive | Minutes to hours; protease-sensitive |
| Amino Acids | 30 | 13 |
| Typical Dose | Research use only; no approved human dose | Research use only; no approved human dose |
| Route | Topical / Research parenteral | Topical / Research parenteral |
| Purity | ≥98% | ≥98% |
| Studies Count | 610 | 240 |
| Research Status | Pre-clinical | Pre-clinical |
HNP-1 Benefits
- ✓neutrophil-derived antimicrobial defense
- ✓broad pathogen killing
- ✓immune cell signaling
- ✓mucosal protection
Indolicidin Benefits
- ✓broad-spectrum bactericidal activity
- ✓anti-biofilm effects
- ✓membrane disruption
- ✓innate immune support
HNP-1 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
Indolicidin Dosing
0.1–10 µM in vitro|1–10 mg/kg in animal models|No established human dose
HNP-1 Side Effects
- ⚠membrane toxicity at high concentrations
- ⚠short in vivo stability
- ⚠potential inflammation amplification
Indolicidin Side Effects
- ⚠cell membrane toxicity at high doses
- ⚠rapid degradation in vivo
- ⚠limited systemic tolerability
Research Overview
HNP-1
HNP-1 has been studied as a key component of neutrophil-mediated host defense against bacteria, fungi, and some enveloped viruses. Literature also reports immunomodulatory effects, including impacts on chemotaxis, cytokine release, and barrier defense.
Indolicidin
Indolicidin has been extensively studied as a prototype antimicrobial peptide with activity against bacteria, fungi, and some viruses. Research has also explored its use in anti-biofilm strategies and as a template for next-generation synthetic antimicrobial peptides.
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