HNP-1 vs Thymogen
Head-to-head comparison of HNP-1 (Human Neutrophil Peptide 1 (Alpha-Defensin 1)) and Thymogen (L-Glutamyl-L-Tryptophan) — benefits, dosing, side effects, research data, and where to buy.
| Property | HNP-1 | Thymogen |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | Human Neutrophil Peptide 1 (Alpha-Defensin 1) | L-Glutamyl-L-Tryptophan |
| Molecular Weight | 3443 Da | 345.34 Da |
| Half-Life | Minutes to hours; protease-sensitive | 1-2 h |
| Amino Acids | 30 | 2 |
| Typical Dose | Research use only; no approved human dose | 100-300 mcg |
| Route | Topical / Research parenteral | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 610 | 60 |
| Research Status | Pre-clinical | Clinical |
HNP-1 Benefits
- ✓neutrophil-derived antimicrobial defense
- ✓broad pathogen killing
- ✓immune cell signaling
- ✓mucosal protection
Thymogen Benefits
- ✓cellular-immune-support
- ✓t-cell-signaling
- ✓recovery-adjunct
- ✓infection-resilience
HNP-1 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
Thymogen Dosing
100-300 mcg/day|intranasal or IM|5-10 day cycles
HNP-1 Side Effects
- ⚠membrane toxicity at high concentrations
- ⚠short in vivo stability
- ⚠potential inflammation amplification
Thymogen Side Effects
- ⚠nasal irritation
- ⚠headache
- ⚠hypersensitivity
Research Overview
HNP-1
HNP-1 has been studied as a key component of neutrophil-mediated host defense against bacteria, fungi, and some enveloped viruses. Literature also reports immunomodulatory effects, including impacts on chemotaxis, cytokine release, and barrier defense.
Thymogen
Thymogen has been studied as a short thymic peptide-like dipeptide with immunoregulatory activity. The literature focuses on lymphocyte function, cytokine modulation, and use in recurrent respiratory infections or immune suppression states.
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