HNP-1 vs Thymopentin
Head-to-head comparison of HNP-1 (Human Neutrophil Peptide 1 (Alpha-Defensin 1)) and Thymopentin (L-Arginyl-L-Lysyl-L-Aspartyl-L-Valyl-L-Tyrosine) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | HNP-1 | Thymopentin |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | Human Neutrophil Peptide 1 (Alpha-Defensin 1) | L-Arginyl-L-Lysyl-L-Aspartyl-L-Valyl-L-Tyrosine |
| Molecular Weight | 3443 Da | 676.78 Da |
| Half-Life | Minutes to hours; protease-sensitive | 10-30 min |
| Amino Acids | 30 | 5 |
| Typical Dose | Research use only; no approved human dose | 1 mg |
| Route | Topical / Research parenteral | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 610 | 90 |
| Research Status | Pre-clinical | Clinical |
HNP-1 Benefits
- ✓neutrophil-derived antimicrobial defense
- ✓broad pathogen killing
- ✓immune cell signaling
- ✓mucosal protection
Thymopentin Benefits
- ✓t-cell maturation
- ✓helper-suppressor balance
- ✓immune recovery
- ✓antiviral-adjunct research
HNP-1 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
Thymopentin Dosing
1 mg SC or IM|2-3x weekly|4-8 week study cycles
HNP-1 Side Effects
- ⚠membrane toxicity at high concentrations
- ⚠short in vivo stability
- ⚠potential inflammation amplification
Thymopentin Side Effects
- ⚠injection-site redness
- ⚠mild fever
- ⚠headache
Research Overview
HNP-1
HNP-1 has been studied as a key component of neutrophil-mediated host defense against bacteria, fungi, and some enveloped viruses. Literature also reports immunomodulatory effects, including impacts on chemotaxis, cytokine release, and barrier defense.
Thymopentin
Thymopentin has a long history of preclinical and clinical investigation as a thymic peptide immunomodulator. Published studies report effects on T-cell subsets, cytokine responses, and immune recovery in recurrent infection settings.
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