HNP-1
Human Neutrophil Peptide 1 (Alpha-Defensin 1)
30 Amino Acids · MW: 3443 Da
Amino Acids
30
Molecular Weight
3443 Da
Half-life
Minutes to hours; protease-sensitive
Research Score
4.6
Studies
610
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is HNP-1?
Human neutrophil peptide 1 is an alpha-defensin stored in neutrophil granules and released during innate immune responses. It contributes to direct pathogen killing and can affect immune cell recruitment and activation.
Key Benefits & Mechanisms
neutrophil-derived antimicrobial defense
broad pathogen killing
immune cell signaling
mucosal protection
Research Summary
HNP-1 has been studied as a key component of neutrophil-mediated host defense against bacteria, fungi, and some enveloped viruses. Literature also reports immunomodulatory effects, including impacts on chemotaxis, cytokine release, and barrier defense.
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