HNP-1 vs Thymalin
Head-to-head comparison of HNP-1 (Human Neutrophil Peptide 1 (Alpha-Defensin 1)) and Thymalin (Calf Thymus Peptide Fraction (Thymalin)) — benefits, dosing, side effects, research data, and where to buy.
| Property | HNP-1 | Thymalin |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | Human Neutrophil Peptide 1 (Alpha-Defensin 1) | Calf Thymus Peptide Fraction (Thymalin) |
| Molecular Weight | 3443 Da | N/A |
| Half-Life | Minutes to hours; protease-sensitive | N/A |
| Amino Acids | 30 | N/A |
| Typical Dose | Research use only; no approved human dose | 5-20 mg |
| Route | Topical / Research parenteral | Intramuscular |
| Purity | ≥98% | ≥98% |
| Studies Count | 610 | 120 |
| Research Status | Pre-clinical | Clinical |
HNP-1 Benefits
- ✓neutrophil-derived antimicrobial defense
- ✓broad pathogen killing
- ✓immune cell signaling
- ✓mucosal protection
Thymalin Benefits
- ✓t-cell support
- ✓leukocyte recovery
- ✓immunomodulation
- ✓infection-resilience
HNP-1 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
Thymalin Dosing
5-10 mg IM daily|3-10 day cycles|repeat cycles after 1-4 weeks if studied
HNP-1 Side Effects
- ⚠membrane toxicity at high concentrations
- ⚠short in vivo stability
- ⚠potential inflammation amplification
Thymalin Side Effects
- ⚠injection-site discomfort
- ⚠transient fever
- ⚠rash/allergy
Research Overview
HNP-1
HNP-1 has been studied as a key component of neutrophil-mediated host defense against bacteria, fungi, and some enveloped viruses. Literature also reports immunomodulatory effects, including impacts on chemotaxis, cytokine release, and barrier defense.
Thymalin
Thymalin appears in Soviet/Russian clinical literature as a thymus peptide complex used to normalize immune parameters after illness, surgery, or radiation exposure. Reports commonly focus on changes in lymphocyte subsets, phagocytic activity, and infection frequency rather than a single isolated peptide mechanism.
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