HNP-1 vs HD5
Head-to-head comparison of HNP-1 (Human Neutrophil Peptide 1 (Alpha-Defensin 1)) and HD5 (Human Alpha-Defensin 5) — benefits, dosing, side effects, research data, and where to buy.
| Property | HNP-1 | HD5 |
|---|---|---|
| Category | Immune Support | Immune Support |
| Full Name | Human Neutrophil Peptide 1 (Alpha-Defensin 1) | Human Alpha-Defensin 5 |
| Molecular Weight | 3443 Da | 3708 Da |
| Half-Life | Minutes to hours; protease-sensitive | Minutes to hours; protease-sensitive |
| Amino Acids | 30 | 32 |
| Typical Dose | Research use only; no approved human dose | Research use only; no approved human dose |
| Route | Topical / Research parenteral | Oral-local gut / Research parenteral |
| Purity | ≥98% | ≥98% |
| Studies Count | 610 | 260 |
| Research Status | Pre-clinical | Pre-clinical |
HNP-1 Benefits
- ✓neutrophil-derived antimicrobial defense
- ✓broad pathogen killing
- ✓immune cell signaling
- ✓mucosal protection
HD5 Benefits
- ✓gut mucosal defense
- ✓antimicrobial activity
- ✓microbiome balance support
- ✓barrier integrity support
HNP-1 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
HD5 Dosing
0.1–10 µM in vitro|1–5 mg/kg in animal models|No established human dose
HNP-1 Side Effects
- ⚠membrane toxicity at high concentrations
- ⚠short in vivo stability
- ⚠potential inflammation amplification
HD5 Side Effects
- ⚠protease sensitivity
- ⚠potential epithelial irritation at high concentrations
- ⚠unknown systemic safety
Research Overview
HNP-1
HNP-1 has been studied as a key component of neutrophil-mediated host defense against bacteria, fungi, and some enveloped viruses. Literature also reports immunomodulatory effects, including impacts on chemotaxis, cytokine release, and barrier defense.
HD5
HD5 has been widely studied in intestinal innate immunity, particularly for its role in defending crypts against bacterial invasion. Preclinical literature supports activity against multiple microbes and links altered HD5 biology with gut barrier dysfunction.
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