HD5
Human Alpha-Defensin 5
32 Amino Acids · MW: 3708 Da
Amino Acids
32
Molecular Weight
3708 Da
Half-life
Minutes to hours; protease-sensitive
Research Score
4.5
Studies
260
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is HD5?
Human alpha-defensin 5 is a major antimicrobial peptide produced by Paneth cells in the small intestine. It helps regulate intestinal microbial balance while contributing to mucosal immune defense.
Key Benefits & Mechanisms
gut mucosal defense
antimicrobial activity
microbiome balance support
barrier integrity support
Research Summary
HD5 has been widely studied in intestinal innate immunity, particularly for its role in defending crypts against bacterial invasion. Preclinical literature supports activity against multiple microbes and links altered HD5 biology with gut barrier dysfunction.
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