TFF3 vs P11-4
Head-to-head comparison of TFF3 (Trefoil Factor 3 (intestinal trefoil factor)) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
| Property | TFF3 | P11-4 |
|---|---|---|
| Category | Gastrointestinal | Dental & Oral |
| Full Name | Trefoil Factor 3 (intestinal trefoil factor) | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | 6370 Da | 1466 Da |
| Half-Life | unknown; likely short in circulation | local activity for hours; peptide degraded over time |
| Amino Acids | 59 | 11 |
| Typical Dose | research-only; model-dependent microgram to milligram ranges | 0.5-5 mg per lesion |
| Route | Oral/Intrarectal | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 70 | 40 |
| Research Status | Pre-clinical | Clinical |
TFF3 Benefits
- ✓epithelial-restitution
- ✓mucus-support
- ✓wound-healing
- ✓barrier-stability
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
TFF3 Dosing
preclinical dosing varies widely by model|local or systemic administration|repeated dosing for inflammatory injury studies
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
TFF3 Side Effects
- ⚠limited human dosing data
- ⚠protein stability issues
- ⚠potential immunogenicity with exogenous use
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
TFF3
TFF3 is a well-established mucosal repair factor in the literature, especially in the context of intestinal injury and inflammation. Experimental studies support a role in accelerating restitution and protecting the epithelial surface in gut disease models.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
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