Tesofensine vs Cholecystokinin-8
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | Cholecystokinin-8 |
|---|---|---|
| Category | Weight Management | Endocrine Peptides |
| Full Name | Tesofensine (NS2330) | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) |
| Molecular Weight | 426.52 g/mol | 1143.2 Da |
| Half-Life | ~200-300 hours | 1-2 min |
| Amino Acids | Small molecule | DY(SO3H)MGWMDF-NH2 |
| Typical Dose | — | physiologic low-picomolar-nanomolar range|research-dependent |
| Route | — | endogenous secretion|research IV/SC |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 97 |
| Research Status | Phase III Clinical Trials | Endogenous |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.