Tesofensine vs Mazdutide
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and Mazdutide (IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | Mazdutide |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | Tesofensine (NS2330) | IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist |
| Molecular Weight | 426.52 g/mol | ~5,000 Da |
| Half-Life | ~200-300 hours | 5-7 days |
| Amino Acids | Small molecule | 37 |
| Typical Dose | — | 1-6 mg weekly in obesity trials |
| Route | — | Subcutaneous |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 28 |
| Research Status | Phase III Clinical Trials | Clinical |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
Mazdutide Benefits
- ✓clinically meaningful weight loss
- ✓better glycemic control
- ✓reduced waist circumference
- ✓improved lipid profile
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
Mazdutide Dosing
Once-weekly SC titration|Dose escalation every 4 weeks|Use with lifestyle modification
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
Mazdutide Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠constipation
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
Mazdutide
Clinical programs have shown substantial reductions in body weight and improvements in cardiometabolic risk markers. It is a prominent newer dual agonist in the obesity literature.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.