Tesofensine vs Cotadutide
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and Cotadutide (MEDI0382, long-acting GLP-1 and glucagon receptor dual agonist) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | Cotadutide |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | Tesofensine (NS2330) | MEDI0382, long-acting GLP-1 and glucagon receptor dual agonist |
| Molecular Weight | 426.52 g/mol | ~4,700 Da |
| Half-Life | ~200-300 hours | Approximately 24 hours |
| Amino Acids | Small molecule | 37 |
| Typical Dose | — | 0.3-3 mg daily in clinical studies |
| Route | — | Subcutaneous |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 18 |
| Research Status | Phase III Clinical Trials | Clinical |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
Cotadutide Benefits
- ✓body-weight reduction
- ✓improved insulin sensitivity
- ✓reduced hepatic fat
- ✓appetite suppression
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
Cotadutide Dosing
Once-daily SC in trials|Start low and titrate based on tolerance|Monitor GI adverse effects
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
Cotadutide Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠diarrhea
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
Cotadutide
Phase 2 studies reported dose-dependent weight loss and favorable changes in glycemic and liver-related markers. It is one of the most cited synthetic dual-agonist peptides for obesity research.
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