Tesofensine vs Dulaglutide
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and Dulaglutide (Recombinant GLP-1 receptor agonist Fc fusion protein) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | Dulaglutide |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | Tesofensine (NS2330) | Recombinant GLP-1 receptor agonist Fc fusion protein |
| Molecular Weight | 426.52 g/mol | ~63,000 Da |
| Half-Life | ~200-300 hours | About 5 days |
| Amino Acids | Small molecule | N/A |
| Typical Dose | — | 0.75-4.5 mg weekly |
| Route | — | Subcutaneous |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 700 |
| Research Status | Phase III Clinical Trials | Approved |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
Dulaglutide Benefits
- ✓modest weight loss
- ✓lower A1c
- ✓weekly dosing convenience
- ✓cardiometabolic benefit
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
Dulaglutide Dosing
0.75-4.5 mg SC weekly|Increase based on response and tolerance|Administer on the same day each week
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
Dulaglutide Side Effects
- ⚠nausea
- ⚠diarrhea
- ⚠injection-site reactions
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
Dulaglutide
Dulaglutide has repeatedly shown small-to-moderate reductions in body weight alongside glycemic improvement in large diabetes trials. It is a useful comparator for GLP-1 receptor agonist effects on appetite and weight.
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