Mazdutide vs HM15211
Head-to-head comparison of Mazdutide (IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist) and HM15211 (HM15211, glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide/glucagon receptor triagonist) — benefits, dosing, side effects, research data, and where to buy.
| Property | Mazdutide | HM15211 |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist | HM15211, glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide/glucagon receptor triagonist |
| Molecular Weight | ~5,000 Da | N/A |
| Half-Life | 5-7 days | Approximately 1 week |
| Amino Acids | 37 | N/A |
| Typical Dose | 1-6 mg weekly in obesity trials | Investigational; no established human dose |
| Route | Subcutaneous | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 28 | 12 |
| Research Status | Clinical | Clinical |
Mazdutide Benefits
- ✓clinically meaningful weight loss
- ✓better glycemic control
- ✓reduced waist circumference
- ✓improved lipid profile
HM15211 Benefits
- ✓appetite suppression
- ✓greater fat oxidation
- ✓weight loss
- ✓improved metabolic markers
Mazdutide Dosing
Once-weekly SC titration|Dose escalation every 4 weeks|Use with lifestyle modification
HM15211 Dosing
once-weekly subcutaneous injection|titration to effect|maintenance at tolerated dose
Mazdutide Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠constipation
HM15211 Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠reduced appetite
Research Overview
Mazdutide
Clinical programs have shown substantial reductions in body weight and improvements in cardiometabolic risk markers. It is a prominent newer dual agonist in the obesity literature.
HM15211
Research has shown potent weight-reducing and metabolic effects in preclinical and translational studies. The compound is being developed as a next-generation incretin-based therapy.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.