HM15211

HM15211, glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide/glucagon receptor triagonist

N/A Amino Acids · MW: N/A

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Amino Acids

N/A

Molecular Weight

N/A

Half-life

Approximately 1 week

Research Score

4.3

Studies

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is HM15211?

HM15211 is a triagonist that activates GLP-1, GIP, and glucagon receptors to target obesity and metabolic dysfunction. It is designed to combine strong weight-loss efficacy with broader metabolic benefits than single-pathway agents.

Key Benefits & Mechanisms

appetite suppression

greater fat oxidation

weight loss

improved metabolic markers

Research Summary

Research has shown potent weight-reducing and metabolic effects in preclinical and translational studies. The compound is being developed as a next-generation incretin-based therapy.

Related Peptides

Oxyntomodulin

Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide

Oxyntomodulin is a naturally occurring proglucagon-derived peptide that activates GLP-1 and glucagon pathways. It is a key research tool for appetite suppression and energy balance studies in obesity.

Weight Management

Cotadutide

MEDI0382, long-acting GLP-1 and glucagon receptor dual agonist

Cotadutide is a synthetic oxyntomodulin analogue designed to engage both GLP-1 and glucagon receptors. It was developed to improve weight loss and metabolic markers in obesity and type 2 diabetes research.

Weight Management

Mazdutide

IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist

Mazdutide is a long-acting oxyntomodulin-inspired dual agonist being developed for obesity and metabolic disease. It is designed to drive clinically meaningful weight loss while improving glucose and lipid parameters.

Weight Management

Dulaglutide

Recombinant GLP-1 receptor agonist Fc fusion protein

Dulaglutide is a long-acting GLP-1 receptor agonist used primarily in type 2 diabetes. It consistently produces modest weight loss and is widely studied as a benchmark incretin mimetic.

Weight Management