Tesofensine vs Bremelanotide
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and Bremelanotide (Bremelanotide (PT-141), cyclic melanocortin receptor agonist) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | Bremelanotide |
|---|---|---|
| Category | Weight Management | Sexual Health |
| Full Name | Tesofensine (NS2330) | Bremelanotide (PT-141), cyclic melanocortin receptor agonist |
| Molecular Weight | 426.52 g/mol | 1025.2 Da |
| Half-Life | ~200-300 hours | about 2.7 h |
| Amino Acids | Small molecule | 7 |
| Typical Dose | — | 1.75 mg |
| Route | — | Subcutaneous |
| Purity | >98% | ≥98% |
| Studies Count | 35 | 200 |
| Research Status | Phase III Clinical Trials | Clinical |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
Bremelanotide Benefits
- ✓increases sexual desire
- ✓supports arousal
- ✓may improve erectile response
- ✓on-demand use
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
Bremelanotide Dosing
1.75 mg subcutaneous PRN|administer about 45 minutes before activity|max 1 dose per 24 hours
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
Bremelanotide Side Effects
- ⚠nausea
- ⚠flushing
- ⚠headache
- ⚠transient blood pressure increase
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
Bremelanotide
Human studies and approval data support meaningful effects on sexual desire in women, with a central mechanism involving melanocortin signaling. It is one of the most clinically relevant peptides in this category and is commonly used as the reference compound for PT-141-type research.
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