Tesofensine vs 5-Amino-1MQ
Head-to-head comparison of Tesofensine (Tesofensine (NS2330)) and 5-Amino-1MQ (5-Amino-1-methylquinolinium) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Tesofensine | 5-Amino-1MQ |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | Tesofensine (NS2330) | 5-Amino-1-methylquinolinium |
| Molecular Weight | 426.52 g/mol | 178.23 g/mol |
| Half-Life | ~200-300 hours | ~6 hours |
| Amino Acids | Small molecule | Small molecule |
| Typical Dose | — | — |
| Route | — | — |
| Purity | >98% | >98% |
| Studies Count | 35 | 28 |
| Research Status | Phase III Clinical Trials | Active Research |
Tesofensine Benefits
- ✓Potent appetite suppression, increased metabolic rate, enhanced thermogenesis, improved mood during dieting, reduces food reward-seeking behavior
5-Amino-1MQ Benefits
- ✓Reduces body fat without appetite changes, lowers cholesterol, increases NAD+ levels, improves metabolic efficiency, supports cellular energy production
Tesofensine Dosing
Clinical doses: 0.25-1.0 mg orally once daily. Research typically uses 0.5 mg. Extremely long half-life (8-13 days) means steady-state in 7-10 days.
5-Amino-1MQ Dosing
Research doses: 50-150 mg orally daily. Often cycled 8-12 weeks on, 4 weeks off. Best taken in the morning.
Tesofensine Side Effects
- ⚠Dry mouth, insomnia, constipation, increased heart rate, elevated blood pressure. Not recommended with uncontrolled hypertension.
5-Amino-1MQ Side Effects
- ⚠Generally well-tolerated in preclinical models. Potential mild GI discomfort and headache. Long-term human safety data is limited.
Research Overview
Tesofensine
Phase II trials showed 12.8 kg average weight loss at 1.0 mg dose over 6 months. Simultaneously inhibits reuptake of norepinephrine, dopamine, and serotonin, producing appetite suppression and increased thermogenesis.
5-Amino-1MQ
Studies in diet-induced obese mice showed significant reductions in body weight, white adipose tissue mass, and cholesterol levels without changes in food intake. Works by inhibiting NNMT enzyme to increase NAD+ and activate sirtuins.
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