5-Amino-1MQ vs BI 456906
Head-to-head comparison of 5-Amino-1MQ (5-Amino-1-methylquinolinium) and BI 456906 (BI 456906, glucagon-like peptide-1/glucagon receptor dual agonist) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | 5-Amino-1MQ | BI 456906 |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | 5-Amino-1-methylquinolinium | BI 456906, glucagon-like peptide-1/glucagon receptor dual agonist |
| Molecular Weight | 178.23 g/mol | N/A |
| Half-Life | ~6 hours | Approximately 1 week |
| Amino Acids | Small molecule | N/A |
| Typical Dose | — | Trial-dependent; weekly SC dosing |
| Route | — | Subcutaneous |
| Purity | >98% | ≥98% |
| Studies Count | 28 | 10 |
| Research Status | Active Research | Clinical |
5-Amino-1MQ Benefits
- ✓Reduces body fat without appetite changes, lowers cholesterol, increases NAD+ levels, improves metabolic efficiency, supports cellular energy production
BI 456906 Benefits
- ✓weight reduction
- ✓improved glucose control
- ✓lower liver-fat burden
- ✓enhanced satiety
5-Amino-1MQ Dosing
Research doses: 50-150 mg orally daily. Often cycled 8-12 weeks on, 4 weeks off. Best taken in the morning.
BI 456906 Dosing
once-weekly subcutaneous injection|stepwise titration|ongoing maintenance phase
5-Amino-1MQ Side Effects
- ⚠Generally well-tolerated in preclinical models. Potential mild GI discomfort and headache. Long-term human safety data is limited.
BI 456906 Side Effects
- ⚠nausea
- ⚠abdominal discomfort
- ⚠diarrhea
Research Overview
5-Amino-1MQ
Studies in diet-induced obese mice showed significant reductions in body weight, white adipose tissue mass, and cholesterol levels without changes in food intake. Works by inhibiting NNMT enzyme to increase NAD+ and activate sirtuins.
BI 456906
Preclinical and early clinical research support meaningful metabolic effects with a tolerable safety profile. It remains investigational and is not commercially available.
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