5-Amino-1MQ vs Cotadutide
Head-to-head comparison of 5-Amino-1MQ (5-Amino-1-methylquinolinium) and Cotadutide (MEDI0382, long-acting GLP-1 and glucagon receptor dual agonist) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | 5-Amino-1MQ | Cotadutide |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | 5-Amino-1-methylquinolinium | MEDI0382, long-acting GLP-1 and glucagon receptor dual agonist |
| Molecular Weight | 178.23 g/mol | ~4,700 Da |
| Half-Life | ~6 hours | Approximately 24 hours |
| Amino Acids | Small molecule | 37 |
| Typical Dose | — | 0.3-3 mg daily in clinical studies |
| Route | — | Subcutaneous |
| Purity | >98% | ≥98% |
| Studies Count | 28 | 18 |
| Research Status | Active Research | Clinical |
5-Amino-1MQ Benefits
- ✓Reduces body fat without appetite changes, lowers cholesterol, increases NAD+ levels, improves metabolic efficiency, supports cellular energy production
Cotadutide Benefits
- ✓body-weight reduction
- ✓improved insulin sensitivity
- ✓reduced hepatic fat
- ✓appetite suppression
5-Amino-1MQ Dosing
Research doses: 50-150 mg orally daily. Often cycled 8-12 weeks on, 4 weeks off. Best taken in the morning.
Cotadutide Dosing
Once-daily SC in trials|Start low and titrate based on tolerance|Monitor GI adverse effects
5-Amino-1MQ Side Effects
- ⚠Generally well-tolerated in preclinical models. Potential mild GI discomfort and headache. Long-term human safety data is limited.
Cotadutide Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠diarrhea
Research Overview
5-Amino-1MQ
Studies in diet-induced obese mice showed significant reductions in body weight, white adipose tissue mass, and cholesterol levels without changes in food intake. Works by inhibiting NNMT enzyme to increase NAD+ and activate sirtuins.
Cotadutide
Phase 2 studies reported dose-dependent weight loss and favorable changes in glycemic and liver-related markers. It is one of the most cited synthetic dual-agonist peptides for obesity research.
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