5-Amino-1MQ vs Oxyntomodulin
Head-to-head comparison of 5-Amino-1MQ (5-Amino-1-methylquinolinium) and Oxyntomodulin (Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | 5-Amino-1MQ | Oxyntomodulin |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | 5-Amino-1-methylquinolinium | Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide |
| Molecular Weight | 178.23 g/mol | ~4,200 Da |
| Half-Life | ~6 hours | 12-15 minutes |
| Amino Acids | Small molecule | 37 |
| Typical Dose | — | Research doses vary; commonly 100-300 mcg in small human studies |
| Route | — | Subcutaneous/IV |
| Purity | >98% | ≥98% |
| Studies Count | 28 | 80 |
| Research Status | Active Research | Clinical |
5-Amino-1MQ Benefits
- ✓Reduces body fat without appetite changes, lowers cholesterol, increases NAD+ levels, improves metabolic efficiency, supports cellular energy production
Oxyntomodulin Benefits
- ✓reduces appetite
- ✓increases satiety
- ✓supports weight loss
- ✓improves postprandial metabolic signaling
5-Amino-1MQ Dosing
Research doses: 50-150 mg orally daily. Often cycled 8-12 weeks on, 4 weeks off. Best taken in the morning.
Oxyntomodulin Dosing
Research-only dosing|Subcutaneous or IV administration in trials|Pair with calorie restriction and monitoring
5-Amino-1MQ Side Effects
- ⚠Generally well-tolerated in preclinical models. Potential mild GI discomfort and headache. Long-term human safety data is limited.
Oxyntomodulin Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠decreased appetite beyond target
Research Overview
5-Amino-1MQ
Studies in diet-induced obese mice showed significant reductions in body weight, white adipose tissue mass, and cholesterol levels without changes in food intake. Works by inhibiting NNMT enzyme to increase NAD+ and activate sirtuins.
Oxyntomodulin
Human studies showed acute reductions in food intake and modest weight loss, helping establish the GLP-1 and glucagon co-agonism concept. It remains a foundational peptide for obesity and satiety research.
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