Oxyntomodulin vs BI 456906
Head-to-head comparison of Oxyntomodulin (Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide) and BI 456906 (BI 456906, glucagon-like peptide-1/glucagon receptor dual agonist) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Oxyntomodulin | BI 456906 |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide | BI 456906, glucagon-like peptide-1/glucagon receptor dual agonist |
| Molecular Weight | ~4,200 Da | N/A |
| Half-Life | 12-15 minutes | Approximately 1 week |
| Amino Acids | 37 | N/A |
| Typical Dose | Research doses vary; commonly 100-300 mcg in small human studies | Trial-dependent; weekly SC dosing |
| Route | Subcutaneous/IV | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 80 | 10 |
| Research Status | Clinical | Clinical |
Oxyntomodulin Benefits
- ✓reduces appetite
- ✓increases satiety
- ✓supports weight loss
- ✓improves postprandial metabolic signaling
BI 456906 Benefits
- ✓weight reduction
- ✓improved glucose control
- ✓lower liver-fat burden
- ✓enhanced satiety
Oxyntomodulin Dosing
Research-only dosing|Subcutaneous or IV administration in trials|Pair with calorie restriction and monitoring
BI 456906 Dosing
once-weekly subcutaneous injection|stepwise titration|ongoing maintenance phase
Oxyntomodulin Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠decreased appetite beyond target
BI 456906 Side Effects
- ⚠nausea
- ⚠abdominal discomfort
- ⚠diarrhea
Research Overview
Oxyntomodulin
Human studies showed acute reductions in food intake and modest weight loss, helping establish the GLP-1 and glucagon co-agonism concept. It remains a foundational peptide for obesity and satiety research.
BI 456906
Preclinical and early clinical research support meaningful metabolic effects with a tolerable safety profile. It remains investigational and is not commercially available.
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