Oxyntomodulin vs Dulaglutide
Head-to-head comparison of Oxyntomodulin (Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide) and Dulaglutide (Recombinant GLP-1 receptor agonist Fc fusion protein) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Oxyntomodulin | Dulaglutide |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide | Recombinant GLP-1 receptor agonist Fc fusion protein |
| Molecular Weight | ~4,200 Da | ~63,000 Da |
| Half-Life | 12-15 minutes | About 5 days |
| Amino Acids | 37 | N/A |
| Typical Dose | Research doses vary; commonly 100-300 mcg in small human studies | 0.75-4.5 mg weekly |
| Route | Subcutaneous/IV | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 80 | 700 |
| Research Status | Clinical | Approved |
Oxyntomodulin Benefits
- ✓reduces appetite
- ✓increases satiety
- ✓supports weight loss
- ✓improves postprandial metabolic signaling
Dulaglutide Benefits
- ✓modest weight loss
- ✓lower A1c
- ✓weekly dosing convenience
- ✓cardiometabolic benefit
Oxyntomodulin Dosing
Research-only dosing|Subcutaneous or IV administration in trials|Pair with calorie restriction and monitoring
Dulaglutide Dosing
0.75-4.5 mg SC weekly|Increase based on response and tolerance|Administer on the same day each week
Oxyntomodulin Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠decreased appetite beyond target
Dulaglutide Side Effects
- ⚠nausea
- ⚠diarrhea
- ⚠injection-site reactions
Research Overview
Oxyntomodulin
Human studies showed acute reductions in food intake and modest weight loss, helping establish the GLP-1 and glucagon co-agonism concept. It remains a foundational peptide for obesity and satiety research.
Dulaglutide
Dulaglutide has repeatedly shown small-to-moderate reductions in body weight alongside glycemic improvement in large diabetes trials. It is a useful comparator for GLP-1 receptor agonist effects on appetite and weight.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.