Oxyntomodulin vs Mazdutide
Head-to-head comparison of Oxyntomodulin (Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide) and Mazdutide (IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Oxyntomodulin | Mazdutide |
|---|---|---|
| Category | Weight Management | Weight Management |
| Full Name | Endogenous glucagon-like peptide 1 and glucagon co-agonist peptide | IBI362, long-acting GLP-1 receptor and glucagon receptor dual agonist |
| Molecular Weight | ~4,200 Da | ~5,000 Da |
| Half-Life | 12-15 minutes | 5-7 days |
| Amino Acids | 37 | 37 |
| Typical Dose | Research doses vary; commonly 100-300 mcg in small human studies | 1-6 mg weekly in obesity trials |
| Route | Subcutaneous/IV | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 80 | 28 |
| Research Status | Clinical | Clinical |
Oxyntomodulin Benefits
- ✓reduces appetite
- ✓increases satiety
- ✓supports weight loss
- ✓improves postprandial metabolic signaling
Mazdutide Benefits
- ✓clinically meaningful weight loss
- ✓better glycemic control
- ✓reduced waist circumference
- ✓improved lipid profile
Oxyntomodulin Dosing
Research-only dosing|Subcutaneous or IV administration in trials|Pair with calorie restriction and monitoring
Mazdutide Dosing
Once-weekly SC titration|Dose escalation every 4 weeks|Use with lifestyle modification
Oxyntomodulin Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠decreased appetite beyond target
Mazdutide Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠constipation
Research Overview
Oxyntomodulin
Human studies showed acute reductions in food intake and modest weight loss, helping establish the GLP-1 and glucagon co-agonism concept. It remains a foundational peptide for obesity and satiety research.
Mazdutide
Clinical programs have shown substantial reductions in body weight and improvements in cardiometabolic risk markers. It is a prominent newer dual agonist in the obesity literature.
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