Secretin vs P11-4
Head-to-head comparison of Secretin (Human Secretin) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Secretin | P11-4 |
|---|---|---|
| Category | Gastrointestinal | Dental & Oral |
| Full Name | Human Secretin | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | 3055.4 Da | 1466 Da |
| Half-Life | 5-7 minutes | local activity for hours; peptide degraded over time |
| Amino Acids | 27 | 11 |
| Typical Dose | 0.2 mcg/kg IV | 0.5-5 mg per lesion |
| Route | Intravenous | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 40 |
| Research Status | Clinical | Clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.