Roxadustat vs REGN1033
Head-to-head comparison of Roxadustat (Roxadustat (FG-4592), hypoxia-inducible factor prolyl hydroxylase inhibitor) and REGN1033 (Trevogrumab (REGN1033)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Roxadustat | REGN1033 |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Roxadustat (FG-4592), hypoxia-inducible factor prolyl hydroxylase inhibitor | Trevogrumab (REGN1033) |
| Molecular Weight | 352.35 Da | ~150 kDa |
| Half-Life | ~12-16 h | ~2-3 weeks |
| Amino Acids | N/A | N/A |
| Typical Dose | 70-100 mg orally three times weekly | 100-300 mg SC or equivalent trial dosing |
| Route | Oral | Subcutaneous / Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 180 | 60 |
| Research Status | Clinical | Clinical |
Roxadustat Benefits
- ✓induces endogenous EPO
- ✓improves iron handling
- ✓raises hemoglobin
- ✓may improve exercise tolerance
REGN1033 Benefits
- ✓myostatin blockade
- ✓lean-mass preservation
- ✓muscle hypertrophy support
- ✓catabolic-state countermeasure
Roxadustat Dosing
70-100 mg orally 3x weekly|Titrate by hemoglobin response|Monitor iron indices regularly
REGN1033 Dosing
SC or IV clinical-trial dosing|repeat every 2-4 weeks|dose escalation by study
Roxadustat Side Effects
- ⚠nausea
- ⚠hypertension
- ⚠thrombotic events
REGN1033 Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠fatigue
Research Overview
Roxadustat
Large clinical studies support roxadustat for anemia, especially in chronic kidney disease populations. Direct VO2 max enhancement data in healthy athletes are limited, so its performance effects remain mostly inferential.
REGN1033
Human and animal studies indicate that myostatin neutralization can increase muscle size, though functional gains are often smaller than mass gains. Trevogrumab is part of the broader literature showing that selective myostatin inhibition can alter body composition in clinically meaningful ways.
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