Roxadustat vs FS315
Head-to-head comparison of Roxadustat (Roxadustat (FG-4592), hypoxia-inducible factor prolyl hydroxylase inhibitor) and FS315 (Follistatin-315 (FS315)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Roxadustat | FS315 |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Roxadustat (FG-4592), hypoxia-inducible factor prolyl hydroxylase inhibitor | Follistatin-315 (FS315) |
| Molecular Weight | 352.35 Da | ~40 kDa |
| Half-Life | ~12-16 h | N/A; depends on construct/delivery |
| Amino Acids | N/A | 315 |
| Typical Dose | 70-100 mg orally three times weekly | Research-only; no standardized human dose |
| Route | Oral | Intramuscular / research expression systems |
| Purity | ≥98% | ≥98% |
| Studies Count | 180 | 95 |
| Research Status | Clinical | Pre-clinical |
Roxadustat Benefits
- ✓induces endogenous EPO
- ✓improves iron handling
- ✓raises hemoglobin
- ✓may improve exercise tolerance
FS315 Benefits
- ✓activin neutralization
- ✓muscle growth signaling
- ✓anti-catabolic support
- ✓tissue repair modulation
Roxadustat Dosing
70-100 mg orally 3x weekly|Titrate by hemoglobin response|Monitor iron indices regularly
FS315 Dosing
Research-only recombinant/protein-expression studies|no standardized clinical dose|route varies by platform
Roxadustat Side Effects
- ⚠nausea
- ⚠hypertension
- ⚠thrombotic events
FS315 Side Effects
- ⚠off-target endocrine effects
- ⚠immune response risk
- ⚠fluid balance changes
Research Overview
Roxadustat
Large clinical studies support roxadustat for anemia, especially in chronic kidney disease populations. Direct VO2 max enhancement data in healthy athletes are limited, so its performance effects remain mostly inferential.
FS315
Follistatin-315 is a key reference isoform in studies of muscle anabolism and reproductive/endocrine biology. In muscle research, it is relevant because it suppresses activin and can indirectly blunt myostatin pathway output.
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