Roxadustat vs ACE-031
Head-to-head comparison of Roxadustat (Roxadustat (FG-4592), hypoxia-inducible factor prolyl hydroxylase inhibitor) and ACE-031 (ACE-031 (soluble activin receptor type IIB-Fc)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Roxadustat | ACE-031 |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Roxadustat (FG-4592), hypoxia-inducible factor prolyl hydroxylase inhibitor | ACE-031 (soluble activin receptor type IIB-Fc) |
| Molecular Weight | 352.35 Da | ~95 kDa |
| Half-Life | ~12-16 h | Days to weeks |
| Amino Acids | N/A | N/A |
| Typical Dose | 70-100 mg orally three times weekly | 0.1-3 mg/kg in early studies |
| Route | Oral | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 180 | 75 |
| Research Status | Clinical | Clinical |
Roxadustat Benefits
- ✓induces endogenous EPO
- ✓improves iron handling
- ✓raises hemoglobin
- ✓may improve exercise tolerance
ACE-031 Benefits
- ✓myostatin/activin neutralization
- ✓lean mass gain
- ✓muscle function support
- ✓anti-catabolic effect
Roxadustat Dosing
70-100 mg orally 3x weekly|Titrate by hemoglobin response|Monitor iron indices regularly
ACE-031 Dosing
Clinical studies used single or repeated SC doses|dose escalation in mg/kg|monitoring for edema/bleeding
Roxadustat Side Effects
- ⚠nausea
- ⚠hypertension
- ⚠thrombotic events
ACE-031 Side Effects
- ⚠telangiectasia/vascular effects
- ⚠epistaxis
- ⚠headache/edema
Research Overview
Roxadustat
Large clinical studies support roxadustat for anemia, especially in chronic kidney disease populations. Direct VO2 max enhancement data in healthy athletes are limited, so its performance effects remain mostly inferential.
ACE-031
ACE-031 produced increases in lean mass in early studies, but development was curtailed after safety concerns and variable efficacy. Its literature remains important because it validated activin receptor blockade as a muscle-building strategy.
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