ACE-031 vs Meldonium
Head-to-head comparison of ACE-031 (ACE-031 (soluble activin receptor type IIB-Fc)) and Meldonium (3-(2,2,2-Trimethylhydrazinium)propionate) — benefits, dosing, side effects, research data, and where to buy.
| Property | ACE-031 | Meldonium |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | ACE-031 (soluble activin receptor type IIB-Fc) | 3-(2,2,2-Trimethylhydrazinium)propionate |
| Molecular Weight | ~95 kDa | 146.19 Da |
| Half-Life | Days to weeks | ~3-6 h |
| Amino Acids | N/A | N/A |
| Typical Dose | 0.1-3 mg/kg in early studies | 500-1000 mg/day in divided oral doses |
| Route | Subcutaneous | Oral/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 75 | 70 |
| Research Status | Clinical | Clinical |
ACE-031 Benefits
- ✓myostatin/activin neutralization
- ✓lean mass gain
- ✓muscle function support
- ✓anti-catabolic effect
Meldonium Benefits
- ✓improves exercise tolerance
- ✓may reduce ischemic fatigue
- ✓supports metabolic efficiency
- ✓may aid recovery
ACE-031 Dosing
Clinical studies used single or repeated SC doses|dose escalation in mg/kg|monitoring for edema/bleeding
Meldonium Dosing
500 mg orally daily|500 mg orally twice daily|500-1000 mg/day in divided doses
ACE-031 Side Effects
- ⚠telangiectasia/vascular effects
- ⚠epistaxis
- ⚠headache/edema
Meldonium Side Effects
- ⚠GI upset
- ⚠headache
- ⚠palpitations
Research Overview
ACE-031
ACE-031 produced increases in lean mass in early studies, but development was curtailed after safety concerns and variable efficacy. Its literature remains important because it validated activin receptor blockade as a muscle-building strategy.
Meldonium
Clinical literature focuses on cardiometabolic support and exercise tolerance rather than direct anabolic effects. Any endurance benefit is thought to come from altered substrate handling and improved tolerance to stress.
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