FS315 vs Meldonium
Head-to-head comparison of FS315 (Follistatin-315 (FS315)) and Meldonium (3-(2,2,2-Trimethylhydrazinium)propionate) — benefits, dosing, side effects, research data, and where to buy.
| Property | FS315 | Meldonium |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Follistatin-315 (FS315) | 3-(2,2,2-Trimethylhydrazinium)propionate |
| Molecular Weight | ~40 kDa | 146.19 Da |
| Half-Life | N/A; depends on construct/delivery | ~3-6 h |
| Amino Acids | 315 | N/A |
| Typical Dose | Research-only; no standardized human dose | 500-1000 mg/day in divided oral doses |
| Route | Intramuscular / research expression systems | Oral/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 95 | 70 |
| Research Status | Pre-clinical | Clinical |
FS315 Benefits
- ✓activin neutralization
- ✓muscle growth signaling
- ✓anti-catabolic support
- ✓tissue repair modulation
Meldonium Benefits
- ✓improves exercise tolerance
- ✓may reduce ischemic fatigue
- ✓supports metabolic efficiency
- ✓may aid recovery
FS315 Dosing
Research-only recombinant/protein-expression studies|no standardized clinical dose|route varies by platform
Meldonium Dosing
500 mg orally daily|500 mg orally twice daily|500-1000 mg/day in divided doses
FS315 Side Effects
- ⚠off-target endocrine effects
- ⚠immune response risk
- ⚠fluid balance changes
Meldonium Side Effects
- ⚠GI upset
- ⚠headache
- ⚠palpitations
Research Overview
FS315
Follistatin-315 is a key reference isoform in studies of muscle anabolism and reproductive/endocrine biology. In muscle research, it is relevant because it suppresses activin and can indirectly blunt myostatin pathway output.
Meldonium
Clinical literature focuses on cardiometabolic support and exercise tolerance rather than direct anabolic effects. Any endurance benefit is thought to come from altered substrate handling and improved tolerance to stress.
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