FS315 vs REGN1033
Head-to-head comparison of FS315 (Follistatin-315 (FS315)) and REGN1033 (Trevogrumab (REGN1033)) — benefits, dosing, side effects, research data, and where to buy.
| Property | FS315 | REGN1033 |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Follistatin-315 (FS315) | Trevogrumab (REGN1033) |
| Molecular Weight | ~40 kDa | ~150 kDa |
| Half-Life | N/A; depends on construct/delivery | ~2-3 weeks |
| Amino Acids | 315 | N/A |
| Typical Dose | Research-only; no standardized human dose | 100-300 mg SC or equivalent trial dosing |
| Route | Intramuscular / research expression systems | Subcutaneous / Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 95 | 60 |
| Research Status | Pre-clinical | Clinical |
FS315 Benefits
- ✓activin neutralization
- ✓muscle growth signaling
- ✓anti-catabolic support
- ✓tissue repair modulation
REGN1033 Benefits
- ✓myostatin blockade
- ✓lean-mass preservation
- ✓muscle hypertrophy support
- ✓catabolic-state countermeasure
FS315 Dosing
Research-only recombinant/protein-expression studies|no standardized clinical dose|route varies by platform
REGN1033 Dosing
SC or IV clinical-trial dosing|repeat every 2-4 weeks|dose escalation by study
FS315 Side Effects
- ⚠off-target endocrine effects
- ⚠immune response risk
- ⚠fluid balance changes
REGN1033 Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠fatigue
Research Overview
FS315
Follistatin-315 is a key reference isoform in studies of muscle anabolism and reproductive/endocrine biology. In muscle research, it is relevant because it suppresses activin and can indirectly blunt myostatin pathway output.
REGN1033
Human and animal studies indicate that myostatin neutralization can increase muscle size, though functional gains are often smaller than mass gains. Trevogrumab is part of the broader literature showing that selective myostatin inhibition can alter body composition in clinically meaningful ways.
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