REGN1033 vs Roxadustat
Head-to-head comparison of REGN1033 (Trevogrumab (REGN1033)) and Roxadustat (Roxadustat (FG-4592), hypoxia-inducible factor prolyl hydroxylase inhibitor) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | REGN1033 | Roxadustat |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Trevogrumab (REGN1033) | Roxadustat (FG-4592), hypoxia-inducible factor prolyl hydroxylase inhibitor |
| Molecular Weight | ~150 kDa | 352.35 Da |
| Half-Life | ~2-3 weeks | ~12-16 h |
| Amino Acids | N/A | N/A |
| Typical Dose | 100-300 mg SC or equivalent trial dosing | 70-100 mg orally three times weekly |
| Route | Subcutaneous / Intravenous | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 60 | 180 |
| Research Status | Clinical | Clinical |
REGN1033 Benefits
- ✓myostatin blockade
- ✓lean-mass preservation
- ✓muscle hypertrophy support
- ✓catabolic-state countermeasure
Roxadustat Benefits
- ✓induces endogenous EPO
- ✓improves iron handling
- ✓raises hemoglobin
- ✓may improve exercise tolerance
REGN1033 Dosing
SC or IV clinical-trial dosing|repeat every 2-4 weeks|dose escalation by study
Roxadustat Dosing
70-100 mg orally 3x weekly|Titrate by hemoglobin response|Monitor iron indices regularly
REGN1033 Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠fatigue
Roxadustat Side Effects
- ⚠nausea
- ⚠hypertension
- ⚠thrombotic events
Research Overview
REGN1033
Human and animal studies indicate that myostatin neutralization can increase muscle size, though functional gains are often smaller than mass gains. Trevogrumab is part of the broader literature showing that selective myostatin inhibition can alter body composition in clinically meaningful ways.
Roxadustat
Large clinical studies support roxadustat for anemia, especially in chronic kidney disease populations. Direct VO2 max enhancement data in healthy athletes are limited, so its performance effects remain mostly inferential.
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