REGN1033 vs Epoetin Alfa
Head-to-head comparison of REGN1033 (Trevogrumab (REGN1033)) and Epoetin Alfa (Recombinant human erythropoietin alfa) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | REGN1033 | Epoetin Alfa |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Trevogrumab (REGN1033) | Recombinant human erythropoietin alfa |
| Molecular Weight | ~150 kDa | ≈30,400 Da |
| Half-Life | ~2-3 weeks | ~4-13 h IV; ~20-30 h SC |
| Amino Acids | N/A | 165 |
| Typical Dose | 100-300 mg SC or equivalent trial dosing | 50-100 IU/kg SC 3x weekly or 40,000 IU SC weekly |
| Route | Subcutaneous / Intravenous | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 60 | 320 |
| Research Status | Clinical | Clinical |
REGN1033 Benefits
- ✓myostatin blockade
- ✓lean-mass preservation
- ✓muscle hypertrophy support
- ✓catabolic-state countermeasure
Epoetin Alfa Benefits
- ✓raises hemoglobin
- ✓increases oxygen-carrying capacity
- ✓may increase VO2 max
- ✓improves time-to-exhaustion
REGN1033 Dosing
SC or IV clinical-trial dosing|repeat every 2-4 weeks|dose escalation by study
Epoetin Alfa Dosing
50-100 IU/kg subcutaneous 3x weekly|40,000 IU subcutaneous weekly|Titrate to hemoglobin target under medical supervision
REGN1033 Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠fatigue
Epoetin Alfa Side Effects
- ⚠hypertension
- ⚠thrombosis
- ⚠polycythemia
Research Overview
REGN1033
Human and animal studies indicate that myostatin neutralization can increase muscle size, though functional gains are often smaller than mass gains. Trevogrumab is part of the broader literature showing that selective myostatin inhibition can alter body composition in clinically meaningful ways.
Epoetin Alfa
Human studies in anemia and performance-related settings show that increasing red-cell mass can improve aerobic capacity and endurance. It remains heavily regulated because excessive erythropoiesis raises thrombotic and cardiovascular risk.
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