REGN1033 vs Darbepoetin Alfa
Head-to-head comparison of REGN1033 (Trevogrumab (REGN1033)) and Darbepoetin Alfa (Darbepoetin alfa, recombinant human erythropoiesis-stimulating protein) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | REGN1033 | Darbepoetin Alfa |
|---|---|---|
| Category | Muscle & Performance | Muscle & Performance |
| Full Name | Trevogrumab (REGN1033) | Darbepoetin alfa, recombinant human erythropoiesis-stimulating protein |
| Molecular Weight | ~150 kDa | ≈37,000 Da |
| Half-Life | ~2-3 weeks | ~21 h IV; ~49 h SC |
| Amino Acids | N/A | 165 |
| Typical Dose | 100-300 mg SC or equivalent trial dosing | 0.45 mcg/kg weekly SC or 0.75 mcg/kg every 2 weeks |
| Route | Subcutaneous / Intravenous | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 60 | 210 |
| Research Status | Clinical | Clinical |
REGN1033 Benefits
- ✓myostatin blockade
- ✓lean-mass preservation
- ✓muscle hypertrophy support
- ✓catabolic-state countermeasure
Darbepoetin Alfa Benefits
- ✓longer-acting erythropoiesis
- ✓stable hemoglobin
- ✓increased oxygen delivery
- ✓may improve aerobic capacity
REGN1033 Dosing
SC or IV clinical-trial dosing|repeat every 2-4 weeks|dose escalation by study
Darbepoetin Alfa Dosing
0.45 mcg/kg weekly SC|0.75 mcg/kg every 2 weeks SC|Dose-adjust to hemoglobin response
REGN1033 Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠fatigue
Darbepoetin Alfa Side Effects
- ⚠hypertension
- ⚠thromboembolism
- ⚠headache
Research Overview
REGN1033
Human and animal studies indicate that myostatin neutralization can increase muscle size, though functional gains are often smaller than mass gains. Trevogrumab is part of the broader literature showing that selective myostatin inhibition can alter body composition in clinically meaningful ways.
Darbepoetin Alfa
Clinical studies show durable hemoglobin correction with less frequent dosing than epoetin alfa. The endurance benefit, where present, would come from improved oxygen-carrying capacity rather than a direct ergogenic pathway.
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