PACAP-27 vs P11-4
Head-to-head comparison of PACAP-27 (Pituitary Adenylate Cyclase-Activating Polypeptide-27) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
| Property | PACAP-27 | P11-4 |
|---|---|---|
| Category | Diabetes & Metabolic | Dental & Oral |
| Full Name | Pituitary Adenylate Cyclase-Activating Polypeptide-27 | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | 3158 Da | 1466 Da |
| Half-Life | minutes | local activity for hours; peptide degraded over time |
| Amino Acids | 27 | 11 |
| Typical Dose | Research-only: 0.1-1 nmol/kg | 0.5-5 mg per lesion |
| Route | Intraperitoneal/Subcutaneous | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 220 | 40 |
| Research Status | Pre-clinical | Clinical |
PACAP-27 Benefits
- ✓anti-apoptotic signaling
- ✓insulin secretagogue effect
- ✓reduced ER stress
- ✓islet cytoprotection
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
PACAP-27 Dosing
0.1-1 nmol/kg in animal studies|10-100 nM in vitro|research-only intermittent dosing
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
PACAP-27 Side Effects
- ⚠flushing
- ⚠hypotension at high exposure
- ⚠headache
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
PACAP-27
PACAP-27 has been repeatedly shown to support beta-cell survival through cAMP/PKA and related pathways. In experimental models it mitigates cytokine damage, preserves insulin content, and helps maintain islet viability.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
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