PACAP-27
Pituitary Adenylate Cyclase-Activating Polypeptide-27
27 Amino Acids · MW: 3158 Da
Amino Acids
27
Molecular Weight
3158 Da
Half-life
minutes
Research Score
4.2
Studies
220
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is PACAP-27?
A neuropeptide of the VIP/secretin family with strong anti-apoptotic signaling in islets. It can enhance insulin secretion and protect pancreatic beta cells from inflammatory and oxidative injury.
Key Benefits & Mechanisms
anti-apoptotic signaling
insulin secretagogue effect
reduced ER stress
islet cytoprotection
Research Summary
PACAP-27 has been repeatedly shown to support beta-cell survival through cAMP/PKA and related pathways. In experimental models it mitigates cytokine damage, preserves insulin content, and helps maintain islet viability.
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