P11-4 vs Exendin-4
Head-to-head comparison of P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) and Exendin-4 (Exendin-4 (synthetic exenatide)) — benefits, dosing, side effects, research data, and where to buy.
| Property | P11-4 | Exendin-4 |
|---|---|---|
| Category | Dental & Oral | Diabetes & Metabolic |
| Full Name | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) | Exendin-4 (synthetic exenatide) |
| Molecular Weight | 1466 Da | 4186 Da |
| Half-Life | local activity for hours; peptide degraded over time | 2.4 hours |
| Amino Acids | 11 | 39 |
| Typical Dose | 0.5-5 mg per lesion | 5-10 mcg twice daily |
| Route | Topical/Intraoral | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 1800 |
| Research Status | Clinical | Clinical |
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Exendin-4 Benefits
- ✓beta-cell survival
- ✓glucose-stimulated insulin secretion
- ✓reduced glucolipotoxicity
- ✓lowered HbA1c in clinical use
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Exendin-4 Dosing
5 mcg SC twice daily for 4 weeks|increase to 10 mcg SC twice daily if tolerated|research: 0.1-1 µM in vitro or 1-10 µg/kg in animals
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Exendin-4 Side Effects
- ⚠nausea
- ⚠vomiting
- ⚠injection-site reactions
Research Overview
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
Exendin-4
Exendin-4 helped establish GLP-1 receptor biology in diabetes and remains a classic beta-cell protective peptide. Preclinical studies show reduced beta-cell apoptosis, improved insulin content, and better islet function under metabolic stress.
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