Exendin-4
Exendin-4 (synthetic exenatide)
39 Amino Acids · MW: 4186 Da
Amino Acids
39
Molecular Weight
4186 Da
Half-life
2.4 hours
Research Score
4.8
Studies
1800
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Exendin-4?
A 39-amino-acid GLP-1 receptor agonist originally isolated from Heloderma saliva. It enhances glucose-dependent insulin secretion and shows strong beta-cell anti-apoptotic activity in preclinical diabetes models.
Key Benefits & Mechanisms
beta-cell survival
glucose-stimulated insulin secretion
reduced glucolipotoxicity
lowered HbA1c in clinical use
Research Summary
Exendin-4 helped establish GLP-1 receptor biology in diabetes and remains a classic beta-cell protective peptide. Preclinical studies show reduced beta-cell apoptosis, improved insulin content, and better islet function under metabolic stress.
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