Omentin-1 vs P11-4
Head-to-head comparison of Omentin-1 (Omentin-1 (Intelectin-1, ITLN1)) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Omentin-1 | P11-4 |
|---|---|---|
| Category | Diabetes & Metabolic | Dental & Oral |
| Full Name | Omentin-1 (Intelectin-1, ITLN1) | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | ~35 kDa | 1466 Da |
| Half-Life | hours | local activity for hours; peptide degraded over time |
| Amino Acids | 313 | 11 |
| Typical Dose | No approved human dose; research use only | 0.5-5 mg per lesion |
| Route | IV|SC | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 82 | 40 |
| Research Status | Pre-clinical | Clinical |
Omentin-1 Benefits
- ✓insulin sensitivity
- ✓glucose uptake
- ✓lipid handling
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Omentin-1 Dosing
not established|not established
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Omentin-1 Side Effects
- ⚠unknown
- ⚠immunogenicity risk
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
Omentin-1
Lower omentin-1 levels are often associated with obesity, insulin resistance, and metabolic syndrome. Research continues on its use as a biomarker and as a mechanistic lead for AMPK-linked metabolic interventions.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
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