P11-4 vs PACAP-27
Head-to-head comparison of P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) and PACAP-27 (Pituitary Adenylate Cyclase-Activating Polypeptide-27) — benefits, dosing, side effects, research data, and where to buy.
| Property | P11-4 | PACAP-27 |
|---|---|---|
| Category | Dental & Oral | Diabetes & Metabolic |
| Full Name | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) | Pituitary Adenylate Cyclase-Activating Polypeptide-27 |
| Molecular Weight | 1466 Da | 3158 Da |
| Half-Life | local activity for hours; peptide degraded over time | minutes |
| Amino Acids | 11 | 27 |
| Typical Dose | 0.5-5 mg per lesion | Research-only: 0.1-1 nmol/kg |
| Route | Topical/Intraoral | Intraperitoneal/Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 220 |
| Research Status | Clinical | Pre-clinical |
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
PACAP-27 Benefits
- ✓anti-apoptotic signaling
- ✓insulin secretagogue effect
- ✓reduced ER stress
- ✓islet cytoprotection
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
PACAP-27 Dosing
0.1-1 nmol/kg in animal studies|10-100 nM in vitro|research-only intermittent dosing
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
PACAP-27 Side Effects
- ⚠flushing
- ⚠hypotension at high exposure
- ⚠headache
Research Overview
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
PACAP-27
PACAP-27 has been repeatedly shown to support beta-cell survival through cAMP/PKA and related pathways. In experimental models it mitigates cytokine damage, preserves insulin content, and helps maintain islet viability.
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