Nociceptin vs Met-enkephalin
Head-to-head comparison of Nociceptin (Nociceptin/orphanin FQ) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Nociceptin | Met-enkephalin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Nociceptin/orphanin FQ | Tyr-Gly-Gly-Phe-Met |
| Molecular Weight | 1881.1 Da | 573.67 Da |
| Half-Life | ~minutes | 1-5 minutes in plasma |
| Amino Acids | 17 | 5 |
| Typical Dose | no approved human dose|research-only | 0.1-5 ug per animal |
| Route | intrathecal|intranasal | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 44 | 1200 |
| Research Status | Pre-clinical | Pre-clinical |
Nociceptin Benefits
- ✓allodynia reduction
- ✓central pain modulation
- ✓neuropathic pain research
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Nociceptin Dosing
no established human dose|research-only dosing varies
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Nociceptin Side Effects
- ⚠sedation
- ⚠dysphoria
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Research Overview
Nociceptin
Nociceptin is a major pain-pathway peptide in the spinal cord, brainstem, and trigeminal system. Its relevance to migraine and neuropathic pain is mainly preclinical, where receptor-selective tools are being explored.
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
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