Nociceptin vs Endomorphin-1
Head-to-head comparison of Nociceptin (Nociceptin/orphanin FQ) and Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Nociceptin | Endomorphin-1 |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Nociceptin/orphanin FQ | Tyr-Pro-Trp-Phe-NH2 |
| Molecular Weight | 1881.1 Da | 610.71 Da |
| Half-Life | ~minutes | Minutes in plasma |
| Amino Acids | 17 | 4 |
| Typical Dose | no approved human dose|research-only | 0.1-10 ug per animal |
| Route | intrathecal|intranasal | Intrathecal / subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 44 | 600 |
| Research Status | Pre-clinical | Pre-clinical |
Nociceptin Benefits
- ✓allodynia reduction
- ✓central pain modulation
- ✓neuropathic pain research
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
Nociceptin Dosing
no established human dose|research-only dosing varies
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
Nociceptin Side Effects
- ⚠sedation
- ⚠dysphoria
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Research Overview
Nociceptin
Nociceptin is a major pain-pathway peptide in the spinal cord, brainstem, and trigeminal system. Its relevance to migraine and neuropathic pain is mainly preclinical, where receptor-selective tools are being explored.
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
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