Nociceptin
Nociceptin/orphanin FQ
17 Amino Acids · MW: 1881.1 Da
Amino Acids
17
Molecular Weight
1881.1 Da
Half-life
~minutes
Research Score
5.0
Studies
44
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Nociceptin?
An endogenous opioid-like neuropeptide that acts at the NOP receptor and has bidirectional effects on pain processing. In many neuropathic pain models it reduces allodynia and hyperalgesia, making it a key research peptide for pain circuits.
Key Benefits & Mechanisms
allodynia reduction
central pain modulation
neuropathic pain research
Research Summary
Nociceptin is a major pain-pathway peptide in the spinal cord, brainstem, and trigeminal system. Its relevance to migraine and neuropathic pain is mainly preclinical, where receptor-selective tools are being explored.
Related Peptides
Met-enkephalin
Tyr-Gly-Gly-Phe-Met
Met-enkephalin is an endogenous opioid pentapeptide that acts at opioid receptors and produces measurable antinociception in classic pain models. It is one of the foundational peptides used to study endogenous pain-control pathways and enkephalin metabolism.
Pain ManagementLeu-enkephalin
Tyr-Gly-Gly-Phe-Leu
Leu-enkephalin is an endogenous enkephalin that binds opioid receptors and has well-characterized antinociceptive effects. It is widely used in research on delta-opioid signaling, peptide metabolism, and pain modulation.
Pain ManagementDADLE
[D-Ala2, D-Leu5]-enkephalin
DADLE is a synthetic enkephalin analog designed to improve opioid-receptor activity and analgesic potency relative to natural enkephalins. It is a classic research compound for delta-opioid and spinal analgesia studies.
Pain ManagementDPDPE
[D-Pen2, D-Pen5]-enkephalin
DPDPE is a cyclic enkephalin analog with strong delta-opioid selectivity and a long history in analgesia research. The disulfide-constrained structure makes it a valuable probe for studying receptor selectivity and peptide stability.
Pain Management