MK-677 vs Elamipretide
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Elamipretide (Elamipretide (MTP-131, SS-31)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | MK-677 | Elamipretide |
|---|---|---|
| Category | Growth Hormone | Muscle & Performance |
| Full Name | Ibutamoren Mesylate (MK-677) | Elamipretide (MTP-131, SS-31) |
| Molecular Weight | 528.662 g/mol | 639.8 Da |
| Half-Life | ~24 hours | 1-4 hours |
| Amino Acids | Non-peptide compound | 4 |
| Typical Dose | — | 0.01-0.25 mg/kg/day |
| Route | — | Subcutaneous/Intravenous |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 120 |
| Research Status | Active Research | Clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Elamipretide Benefits
- ✓mitochondrial protection
- ✓reduced oxidative stress
- ✓improved fatigue resistance
- ✓may support exercise tolerance
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Elamipretide Dosing
0.01-0.25 mg/kg/day SC (clinical research)|daily dosing in trials|alternative IV protocols in some studies
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Elamipretide Side Effects
- ⚠nausea
- ⚠injection-site reactions
- ⚠diarrhea
- ⚠headache
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Elamipretide
Clinical and translational studies show elamipretide can improve mitochondrial function and some functional endpoints in mitochondrial disorders. Skeletal muscle research suggests benefits are driven by energy metabolism rather than direct muscle-building effects.
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