Elamipretide vs hGHRH(1-37)OH
Head-to-head comparison of Elamipretide (Elamipretide (MTP-131, SS-31)) and hGHRH(1-37)OH (Human growth hormone-releasing factor (1-37) hydroxyl) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Elamipretide | hGHRH(1-37)OH |
|---|---|---|
| Category | Muscle & Performance | Growth Hormone |
| Full Name | Elamipretide (MTP-131, SS-31) | Human growth hormone-releasing factor (1-37) hydroxyl |
| Molecular Weight | 639.8 Da | N/A |
| Half-Life | 1-4 hours | 5-20 minutes |
| Amino Acids | 4 | 37 |
| Typical Dose | 0.01-0.25 mg/kg/day | 1-2 mcg/kg |
| Route | Subcutaneous/Intravenous | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 60 |
| Research Status | Clinical | Clinical Research |
Elamipretide Benefits
- ✓mitochondrial protection
- ✓reduced oxidative stress
- ✓improved fatigue resistance
- ✓may support exercise tolerance
hGHRH(1-37)OH Benefits
- ✓GH release studies
- ✓minimal-sequence mapping
- ✓receptor pharmacology
- ✓peptide stability research
Elamipretide Dosing
0.01-0.25 mg/kg/day SC (clinical research)|daily dosing in trials|alternative IV protocols in some studies
hGHRH(1-37)OH Dosing
1-2 mcg/kg SC or IV bolus|acute stimulation with serial GH assays|short-course research administration with biomarker monitoring
Elamipretide Side Effects
- ⚠nausea
- ⚠injection-site reactions
- ⚠diarrhea
- ⚠headache
hGHRH(1-37)OH Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient fatigue
Research Overview
Elamipretide
Clinical and translational studies show elamipretide can improve mitochondrial function and some functional endpoints in mitochondrial disorders. Skeletal muscle research suggests benefits are driven by energy metabolism rather than direct muscle-building effects.
hGHRH(1-37)OH
Human GHRF(1-37)OH has appeared in studies examining how loss of C-terminal residues affects biological activity at the GHRH receptor. It is often used alongside other fragments to define structure-activity relationships within the GHRH family.
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