hGHRH(1-37)OH vs hGHRH(1-44)
Head-to-head comparison of hGHRH(1-37)OH (Human growth hormone-releasing factor (1-37) hydroxyl) and hGHRH(1-44) (Human growth hormone-releasing hormone (1-44) amide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | hGHRH(1-37)OH | hGHRH(1-44) |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Human growth hormone-releasing factor (1-37) hydroxyl | Human growth hormone-releasing hormone (1-44) amide |
| Molecular Weight | N/A | N/A |
| Half-Life | 5-20 minutes | 5-15 minutes |
| Amino Acids | 37 | 44 |
| Typical Dose | 1-2 mcg/kg | 0.1-1 mcg/kg |
| Route | Subcutaneous/IV | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 60 | 120 |
| Research Status | Clinical Research | Clinical Research |
hGHRH(1-37)OH Benefits
- ✓GH release studies
- ✓minimal-sequence mapping
- ✓receptor pharmacology
- ✓peptide stability research
hGHRH(1-44) Benefits
- ✓physiologic GH pulse support
- ✓IGF-1 pathway stimulation
- ✓pituitary receptor mapping
- ✓endocrine research tool
hGHRH(1-37)OH Dosing
1-2 mcg/kg SC or IV bolus|acute stimulation with serial GH assays|short-course research administration with biomarker monitoring
hGHRH(1-44) Dosing
0.1-1 mcg/kg SC or IV bolus for stimulation studies|single-dose endocrine challenge with timed GH sampling|pulsatile administration in clamp/infusion experiments
hGHRH(1-37)OH Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient fatigue
hGHRH(1-44) Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient nausea
Research Overview
hGHRH(1-37)OH
Human GHRF(1-37)OH has appeared in studies examining how loss of C-terminal residues affects biological activity at the GHRH receptor. It is often used alongside other fragments to define structure-activity relationships within the GHRH family.
hGHRH(1-44)
Human GHRH(1-44) amide has been used extensively to characterize hypothalamic control of pituitary somatotrophs and the downstream GH/IGF-1 axis. It remains a standard comparator in studies of GHRH agonism, secretion dynamics, and receptor pharmacology.
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