MK-677 vs Davunetide
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Davunetide (Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | MK-677 | Davunetide |
|---|---|---|
| Category | Growth Hormone | Cognitive Enhancement |
| Full Name | Ibutamoren Mesylate (MK-677) | Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ) |
| Molecular Weight | 528.662 g/mol | 796.9 Da |
| Half-Life | ~24 hours | short; minutes to low hours |
| Amino Acids | Non-peptide compound | 8 |
| Typical Dose | — | 1-10 mg/day research range |
| Route | — | Intranasal |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 40 |
| Research Status | Active Research | Clinical/Pre-clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Davunetide Benefits
- ✓neuroprotection
- ✓microtubule support
- ✓attention support
- ✓memory preservation
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Davunetide Dosing
intranasal research dosing|1-10 mg per dose in trials/preclinical work|once or twice daily
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Davunetide Side Effects
- ⚠nasal irritation
- ⚠headache
- ⚠limited efficacy in late-stage trials
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Davunetide
Preclinical work showed davunetide can protect neurons, preserve synaptic structure, and improve performance in memory tasks. Human trials largely focused on neurodegenerative disease outcomes rather than stand-alone nootropic use, but the literature supports CNS activity.
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