Davunetide vs hGHRH(1-40)OH
Head-to-head comparison of Davunetide (Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ)) and hGHRH(1-40)OH (Human growth hormone-releasing factor (1-40) hydroxyl) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Davunetide | hGHRH(1-40)OH |
|---|---|---|
| Category | Cognitive Enhancement | Growth Hormone |
| Full Name | Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ) | Human growth hormone-releasing factor (1-40) hydroxyl |
| Molecular Weight | 796.9 Da | N/A |
| Half-Life | short; minutes to low hours | 5-20 minutes |
| Amino Acids | 8 | 40 |
| Typical Dose | 1-10 mg/day research range | 1-2 mcg/kg |
| Route | Intranasal | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 85 |
| Research Status | Clinical/Pre-clinical | Clinical Research |
Davunetide Benefits
- ✓neuroprotection
- ✓microtubule support
- ✓attention support
- ✓memory preservation
hGHRH(1-40)OH Benefits
- ✓GH secretion research
- ✓fragment-activity comparison
- ✓receptor binding studies
- ✓axis physiology modeling
Davunetide Dosing
intranasal research dosing|1-10 mg per dose in trials/preclinical work|once or twice daily
hGHRH(1-40)OH Dosing
1-2 mcg/kg SC or IV in acute research settings|single-bolus GH stimulation protocols|repeated low-dose administration in comparative studies
Davunetide Side Effects
- ⚠nasal irritation
- ⚠headache
- ⚠limited efficacy in late-stage trials
hGHRH(1-40)OH Side Effects
- ⚠flushing
- ⚠headache
- ⚠lightheadedness
Research Overview
Davunetide
Preclinical work showed davunetide can protect neurons, preserve synaptic structure, and improve performance in memory tasks. Human trials largely focused on neurodegenerative disease outcomes rather than stand-alone nootropic use, but the literature supports CNS activity.
hGHRH(1-40)OH
Human GHRF(1-40)OH has been studied to understand how truncation of the native hormone changes biological potency and half-life. It is a common research tool for mapping minimal active sequences within the GHRH family.
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