Davunetide vs Capromorelin

Head-to-head comparison of Davunetide (Activity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ)) and Capromorelin (Capromorelin hydrochloride) — benefits, dosing, side effects, research data, and where to buy.

Research Score

PropertyDavunetideCapromorelin
CategoryCognitive EnhancementGrowth Hormone
Full NameActivity-Dependent Neuroprotective Protein fragment NAP (NAPVSIPQ)Capromorelin hydrochloride
Molecular Weight796.9 DaN/A
Half-Lifeshort; minutes to low hoursabout 2-3 hours
Amino Acids8N/A
Typical Dose1-10 mg/day research range0.25-2 mg/kg/day
RouteIntranasalOral
Purity≥98%≥98%
Studies Count4055
Research StatusClinical/Pre-clinicalClinical

Davunetide Benefits

  • neuroprotection
  • microtubule support
  • attention support
  • memory preservation

Capromorelin Benefits

  • GH secretagogue activity
  • appetite stimulation
  • oral administration
  • translational animal model utility

Davunetide Dosing

intranasal research dosing|1-10 mg per dose in trials/preclinical work|once or twice daily

Capromorelin Dosing

0.25-2 mg/kg orally in studies|once-daily or protocol-specific dosing|monitor appetite and body weight

Davunetide Side Effects

  • nasal irritation
  • headache
  • limited efficacy in late-stage trials

Capromorelin Side Effects

  • increased appetite
  • vomiting or nausea
  • lethargy

Research Overview

Davunetide

Preclinical work showed davunetide can protect neurons, preserve synaptic structure, and improve performance in memory tasks. Human trials largely focused on neurodegenerative disease outcomes rather than stand-alone nootropic use, but the literature supports CNS activity.

Capromorelin

Research consistently shows capromorelin activates the ghrelin receptor pathway and increases food intake. Human development has been less prominent than veterinary use, but the compound remains a relevant GH secretagogue prototype.

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Common Stacking Partners

Davunetide stacks with:

gpenoopeptdesmopressin

Capromorelin stacks with:

Nutritional supportResistance training
octapeptideADNPneuroprotectionghrelin-receptor-agonistappetite-stimulantgh-secretagogue